亚洲中文字幕精东业久久久久久,热在线视频精品视频,日韩一区二区久久久久久久久,国产精品久久久久精品三级中文国

24小時(shí)*365天服務(wù)熱線: 400-888-1223 | 員工通道
微信二維碼
在線客服
返回頂部

資源下載

DOWNLOAD

客戶中心
在線留言
申請(qǐng)單下載

咨詢熱線: 400-888-1223

學(xué)術(shù)資源

Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status

2017-07-13

Periodontitis results from the interaction between a subgingival biofilm and host immune response. Changes in biofilm composition are thought to disrupt homeostasis between the host and subgingival bacteria resulting in periodontal damage. Chronic systemic inflammatory disorders have been shown to affect the subgingival microbiota and clinical periodontal status. However, this relationship has not been examined in subjects with systemic lupus erythematosus (SLE). The objective of our study was to investigate the influence of SLE on the subgingival microbiota and its connection with periodontal disease and SLE activity. We evaluated 52 patients with SLE compared to 52 subjects without SLE (control group). Subjects were classified as without periodontitis and with periodontitis. Oral microbiota composition was assessed by amplifying the V4 region of 16S rRNA gene from subgingival dental plaque DNA extracts. These amplicons were examined by Illumina MiSeq sequencing. SLE patients exhibited higher prevalence of periodontitis which occurred at a younger age compared to subjects of the control group. More severe forms of periodontitis were found in SLE subjects that had higher bacterial loads and decreased microbial diversity. Bacterial species frequently detected in periodontal disease were observed in higher proportions in SLE patients, even in periodontal healthy sites such asFretibacterium,Prevotella nigrescens, andSelenomonas. Changes in the oral microbiota were linked to increased local inflammation, as demonstrated by higher concentrations of IL-6, IL-17, and IL-33 in SLE patients with periodontitis. SLE is associated with differences in the composition of the microbiota, independently of periodontal status. The online version of this article (doi:10.1186/s40168-017-0252-z) contains supplementary material, which is available to authorized. 








下載路徑 1707/20177135926.pdf

男插女逼啪啪啪软件| 亚洲欧洲日本精品| 福利国产第一视频| 把女生操出水的视频| 男人的下面进女人的下面在线观看| 多男用舌头伺候一女| 精品国产99亚洲一区二区三区| 你懂的在线中文字幕一区| a一级毛片免费高清在线| 国产午夜精品美女视频露脸| 日本欧美一区二区三区| 老湿机69福免费破解版| 97超级免费视频在线观看| 欧美一区二区三区男人的天堂| 爆乳1把你榨干在线观看| 男人草女人的视频免费看| 97超级免费视频在线观看| 熟妇女人妻丰满中文字幕| 大鸡巴插我在线观看| 亚洲乱熟女一区二区三区| 男生操女生无马赛克免费| 国产精品无码一二区免费| 国产精品碰碰现在自| 久久亚洲精品中文字幕一| 97精品人妻人人做人人爽| 涩涩屋操美女视频| 亚洲乱码专区一区二区三区四区| 上萬網友分享a级国产乱| 日韩美女一区二区三区香蕉视频| 欧美黑屌操B内射冒白浆| 91污在线观看一区二区三区| 男人操女人黄片黄色| 综合伊人久久在一二三区| 老司机午夜精品视频无码| 国产精品欧美久久久久久| 欧美日韩国产这里只有精品| 最新的亚洲欧美中文字幕| 美女穿黑丝被大鸡巴猛操| 波多野结衣浴尿解禁在线| 一区二区三区 日韩在线| 人妻含泪让粗大挺进|